The Gonal-f® family of products is one of the leading recombinant human gonadotropin for induction of ovulation and pregnancy in oligo-anovulatory women and the development of multiple follicles in ovulatory women.1
Indicated for controlling ovulation and preventing lutenizing hormone surges.
For final oocyte maturation in ovulation induction and in vitro fertilization.

Reference: 1. Evaluate Ltd. Merck Serono Announces US FDA Approval for Fertility Pen. Accessed October 2017. http://evaluategroup.com/Universal/View.aspx?type=Story&id=463021

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Fertility Medication Information

Only your fertility specialist can choose the right treatment for you, and in some cases, it may involve the use of medications.

About 12% of women of childbearing age face fertility challenges2

Gonal-f®, a follicle-stimulating hormone (FSH), can help encourage the development of the follicles and eggs. 

Please see Full Prescribing Information for Gonal-f® RFF* Redi-ject®, Gonal-f® RFF* and Gonal-f® Multi-Dose

Learn More About Gonal-f®

Ovidrel® PreFilled Syringe mimics the surge of luteinizing hormone (LH), which triggers the final step in the follicular phase. For ovulation induction, the hormone in Ovidrel® PreFilled Syringe is used for final egg maturation as part of the final process of releasing the egg. For in vitro fertilization (IVF), the hormone in Ovidrel® PreFilled Syringe is used for final maturation of eggs that will be collected prior to ovulation.

Please see Full Prescribing Information for Ovidrel® PreFilled Syringe

Learn More About Ovidrel® PreFilled Syringe

Throughout the cycle, a woman's body releases a hormone called estradiol. If the level of estradiol gets too high too early, it can trigger a premature surge of LH, which leads to early ovulation. Cetrotide® (cetrorelix acetate for injection) may be used in controlled ovarian stimulation to delay this surge until the developing follicles are ready.

Please see Full Prescribing Information for Cetrotide®

Learn More About Cetrotide®

Financial Support
There are many barriers to treatment. Cost shouldn’t be one. It’s why we offer a range of savings programs on EMD Serono medications for eligible patients.
Stay up to date on the latest EMD Serono Fertility treatment information.
IMPORTANT RISK INFORMATION Expand+
  • IMPORTANT RISK INFORMATION for Gonal-f® RFF* Redi-ject® (follitropin alfa injection):

    Gonal-f® RFF* Redi-ject® (follitropin alfa injection) is a prescription medicine containing follicle-stimulating hormone (FSH) used in infertile women to:

    • help healthy ovaries develop (mature) and release an egg
    • cause your ovaries to make multiple (more than 1) eggs as part of an Assisted Reproductive Technology (ART) program

    Do not use Gonal-f® RFF Redi-ject® if you:

    • are allergic to recombinant human FSH or any of the ingredients listed on the product carton or insert
    • are pregnant or think you may be pregnant
    • have uncontrolled thyroid or adrenal problems
    • have a tumor in your female organs, including your ovaries, breast, or uterus
    • have a tumor in your brain, such as a tumor in your pituitary or hypothalamus
    • have abnormal bleeding from your uterus or vagina
    • have ovarian cysts or large ovaries, not due to polycystic ovary syndrome (PCOS)

    Before using Gonal-f® RFF Redi-ject®, tell your healthcare provider about your medical history including any prescription or over-the-counter medicines, vitamins and herbal supplements used, whether you have or have had asthma, abdominal surgery, ovarian cysts, polycystic ovarian disease, blood clots (thrombosis) or family history of blood clots, or are breastfeeding or plan to breastfeed.

    Gonal-f® RFF Redi-ject® may cause serious side effects, including severe or fatal allergic reactions. Stop using Gonal-f® RFF Redi-ject® and go to the hospital right away if you have symptoms of an allergic reaction which can include shortness of breath, swelling of your face, itchy, red bumps or rash on your skin (hives).

    Other serious side effects include stomach bloating or pain caused by enlargement of your ovaries, or fluid build-up in your stomach, chest and heart caused by ovarian hyperstimulation syndrome (OHSS). OHSS can require hospitalization and in rare cases has caused death. Call your healthcare provider right away if you have symptoms of OHSS, including trouble breathing, severe lower stomach (pelvic) area pain, decreased urine output, nausea, vomiting, weight gain, and diarrhea. Gonal-f® RFF can also cause or worsen lung problems (including asthma), blood and blood vessel problems (including clots and stroke), or twisting of your ovary, which require medical attention.

    Use of Gonal-f® RFF Redi-ject® can result in pregnancy with more than 1 baby and the birth of multiple babies, miscarriage, or ectopic pregnancy (pregnancy outside your womb). Chances of having a baby with birth defects may increase in a baby born after an ART cycle and can be impacted by maternal age, paternal sperm problems, and genetic background associated with the egg and sperm.

    The most common side effects of Gonal-f® RFF Redi-ject® include headache, stomach pain, stomach bloating, bruising at the injection site, and nausea. Other side effects reported include sinus infections and ovarian cysts. If you have used fertility medicines like Gonal-f® RFF Redi-ject® before to get pregnant, you may have an increased chance of having tumors in your ovary(ies) (including cancer).

    These are not all the possible side effects of Gonal-f® RFF Redi-ject®. For more information, read the product labeling, and ask your healthcare provider or pharmacist.

    Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Use Gonal-f® RFF Redi-ject® as directed and do not change your dose unless directed. Do not share your Gonal-f® RFF Redi-ject® and needles with another person; you may give another person an infection or get an infection from them.

    Carefully review the Gonal-f® RFF Redi-ject® Instructions for Use that comes with the Pen for information about the correct use of Gonal-f® RFF Redi-ject® and follow all training and instruction provided by your healthcare provider.

    *RFF, Revised Formulation Female

    US-RDJ-1013-0006(2)

  • IMPORTANT RISK INFORMATION for Gonal-f® (follitropin alfa for injection):

    Gonal-f® (follitropin alfa for injection) is a prescription medicine containing follicle-stimulating hormone (FSH) used in infertile women to:

    • help healthy ovaries develop (mature) and release an egg
    • cause your ovaries to make multiple (more than 1) eggs as part of an Assisted Reproductive Technology (ART) program

    Gonal-f® can also be prescribed to increase sperm production in men with a rare medical condition.

    Do not use Gonal-f® if you:

    • are allergic to recombinant human FSH or any of the ingredients listed on the product carton or insert
    • are pregnant or think you may be pregnant
    • have uncontrolled thyroid or adrenal problems
    • have a tumor in your female organs, including your ovaries, breast, or uterus
    • have a tumor in your brain, such as a tumor in your pituitary or hypothalamus
    • have abnormal bleeding from your uterus or vagina
    • have ovarian cysts or large ovaries, not due to polycystic ovary syndrome (PCOS)
    • permanent damage to the male sex organs (testes)

    Before using Gonal-f®, tell your healthcare provider about your medical history including any prescription or overthe-counter medicines, vitamins and herbal supplements used, whether you have or have had asthma, abdominal surgery, ovarian cysts, polycystic ovarian disease, blood clots (thrombosis) or family history of blood clots, or are breastfeeding or plan to breastfeed.

    Gonal-f® may cause serious side effects, including severe or fatal allergic reactions. Stop using Gonal-f® and go to the hospital right away if you have symptoms of an allergic reaction which can include shortness of breath, swelling of your face, itchy, red bumps or rash on your skin (hives).

    Other serious side effects include stomach bloating or pain caused by enlargement of your ovaries, or fluid build-up in your stomach, chest and heart caused by ovarian hyperstimulation syndrome (OHSS). OHSS can require hospitalization and in rare cases has caused death. Call your healthcare provider right away if you have symptoms of OHSS, including trouble breathing, severe lower stomach (pelvic) area pain, decreased urine output, nausea, vomiting, weight gain, and diarrhea. Gonal-f® can also cause or worsen lung problems (including asthma), blood and blood vessel problems (including clots and stroke), or twisting of your ovary, which require medical attention.

    Use of Gonal-f® can result in pregnancy with more than 1 baby and the birth of multiple babies, miscarriage, or ectopic pregnancy (pregnancy outside your womb). Chances of having a baby with birth defects may increase in a baby born after an ART cycle and can be impacted by maternal age, paternal sperm problems, and genetic background associated with the egg and sperm.

    The most common side effects of Gonal-f® include headache, stomach pain, stomach bloating, bruising at the injection site, and nausea. Other side effects reported include sinus infections and ovarian cysts. If you have used fertility medicines like Gonal-f® before to get pregnant, you may have an increased chance of having tumors in your ovary(ies) (including cancer).

    In men, common side effects include skin pimples, breast pain and growth, and tiredness.

    These are not all the possible side effects of Gonal-f®. For more information, read the product labeling, and ask your healthcare provider or pharmacist.

    Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Use Gonal-f® as directed and do not change your dose unless directed. Do not share your Gonal-f® and needles with another person; you may give another person an infection or get an infection from them.

    Carefully review the Gonal-f® Multi-dose Patient Information Leaflet that comes with the product and follow all training and instruction provided by your healthcare provider. The injection syringes provided with the product should only be used with Gonal-f® Multi-dose and should not be used to administer any other drug or hormone.

  • IMPORTANT RISK INFORMATION for Gonal-f® RFF* (follitropin alfa for injection):

    Gonal-f® RFF* (follitropin alfa for injection) is a prescription medicine containing follicle-stimulating hormone (FSH) used in infertile women to:

    • help healthy ovaries develop (mature) and release an egg
    • cause your ovaries to make multiple (more than 1) eggs as part of an Assisted ReproductiveTechnology (ART) program

    Do not use Gonal-f® RFF if you:

    • are allergic to recombinant human FSH or any of the ingredients listed on the product carton or insert
    • are pregnant or think you may be pregnant
    • have uncontrolled thyroid or adrenal problems
    • have a tumor in your female organs, including your ovaries, breast, or uterus
    • have a tumor in your brain, such as a tumor in your pituitary or hypothalamus
    • have abnormal bleeding from your uterus or vagina
    • have ovarian cysts or large ovaries, not due to polycystic ovary syndrome (PCOS)

    Before using Gonal-f® RFF, tell your healthcare provider about your medical history including any prescription or over-the-counter medicines, vitamins and herbal supplements used, whether you have or have had asthma, abdominal surgery, ovarian cysts, polycystic ovarian disease, blood clots (thrombosis) or family history of blood clots, or are breastfeeding or plan to breastfeed.

    Gonal-f® RFF may cause serious side effects, including severe or fatal allergic reactions. Stop using Gonal-f® RFF and go to the hospital right away if you have symptoms of an allergic reaction which can include shortness of breath, swelling of your face, itchy, red bumps or rash on your skin (hives).

    Other serious side effects include stomach bloating or pain caused by enlargement of your ovaries, or fluid build-up in your stomach, chest and heart caused by ovarian hyperstimulation syndrome (OHSS). OHSS can require hospitalization and in rare cases has caused death. Call your healthcare provider right away if you have symptoms of OHSS, including trouble breathing, severe lower stomach (pelvic) area pain, decreased urine output, nausea, vomiting, weight gain, and diarrhea. Gonal-f® RFF can also cause or worsen lung problems (including asthma), blood and blood vessel problems (including clots and stroke), or twisting of your ovary, which require medical attention.

    Use of Gonal-f® RFF can result in pregnancy with more than 1 baby and the birth of multiple babies, miscarriage, or ectopic pregnancy (pregnancy outside your womb). Chances of having a baby with birth defects may increase in a baby born after an ART cycle and can be impacted by maternal age, paternal sperm problems, and genetic background associated with the egg and sperm.

    The most common side effects of Gonal-f® RFF include headache, stomach pain, stomach bloating, bruising at the injection site, and nausea. Other side effects reported include sinus infections and ovarian cysts. If you have used fertility medicines like Gonal-f® RFF before to get pregnant, you may have an increased chance of having tumors in your ovary(ies) (including cancer).

    These are not all the possible side effects of Gonal-f® RFF. For more information, read the product labeling, and ask your healthcare provider or pharmacist.

    Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Use Gonal-f® RFF as directed and do not change your dose unless directed. Do not share your Gonal-f® RFF and needles with another person; you may give another person an infection or get an infection from them.

    *RFF, Revised Formulation Female

    US-FOL-1014-0001

  • IMPORTANT INFORMATION ABOUT THE PROPER USE AND RISKS OF CETROTIDE® (cetrorelix acetate for injection):

    What are the uses of Cetrotide® (cetrorelix acetate for injection)?

    Cetrotide® blocks the effects of a natural hormone, called gonadotropin-releasing hormone (GnRH). GnRH controls the secretion of another hormone, called luteinizing hormone (LH), which induces ovulation during the menstrual cycle.

    During hormone treatment for ovarian stimulation, premature ovulation may lead to eggs that are not suitable for fertilization. Cetrotide® blocks such undesirable premature ovulation.

    Who should not use Cetrotide®?

    Cetrotide® should not be used in patients who are pregnant, think they might be pregnant, or are breastfeeding.

    Cetrotide® should not be used in patients with kidney disease.

    Patients that are allergic to cetrorelix acetate, mannitol, or exogenous peptide hormones (medicines similar to Cetrotide®) should not use Cetrotide®. Consult your doctor before taking Cetrotide® if you have had severe allergic reactions.

    What are the possible side effects of Cetrotide®?

    Your doctor should review with you the risks and benefits of using Cetrotide®. As with any medication, report any and all side effects, symptoms, or physical changes to your doctor.

    Mild and short-lasting injection site reddening, itching, swelling, nausea and headache have also been reported. Infrequent cases of serious allergic reactions requiring medical attention have occurred.

    Call your doctor if you have any other side effect or if you are unsure about the effect of this medicine.

    US-CET-0614-0001

  • IMPORTANT INFORMATION ABOUT THE PROPER USE AND RISKS OF OVIDREL® PREFILLED SYRINGE (choriogonadotropin alfa injection):

    What are the uses of Ovidrel® PreFilled Syringe (choriogonadotropin alfa injection)?

    Ovidrel® PreFilled Syringe contains recombinant human choriogonadotropin alfa (hCG), an injectable hormone. This is the hormone that causes your eggs to finish maturing and be released. You may be given Ovidrel® PreFilled Syringe to complete this final stage of your cycle. Doctors specializing in infertility or reproductive health prescribe Ovidrel® PreFilled Syringe to those women trying to have a child but for a variety of reasons need medical assistance. After a thorough medical exam to determine your specific medical condition, your doctor may prescribe Ovidrel® PreFilled Syringe because you require hormone replacement or supplementation as part of your treatment program. Ovidrel® PreFilled Syringe may be one of several drugs prescribed to a patient as part of a treatment program.

    Who should not use Ovidrel® PreFilled Syringe?

    Ovidrel® PreFilled Syringe should not be used in patients who are pregnant or breastfeeding, in patients with primary ovarian failure (the ovaries no longer produce eggs), or in patients with allergies to hCG or any other ingredients in the medication.

    Patients with cancer of the sex organs or brain, or with uncontrolled thyroid or adrenal disease, should not use Ovidrel® PreFilled Syringe. Women with a history of abnormal bleeding from the uterus or vagina or with swollen, enlarged, or painful ovaries should speak to their doctor before starting treatment.

    In infertile women undergoing assisted reproductive technologies (ART) and ovulation induction (OI), Ovidrel® PreFilled Syringe should not be administered until adequate follicular development is indicated by serum estradiol and vaginal ultrasonography.

    Ovidrel® PreFilled Syringe administration should be withheld in situations where there is an excessive ovarian response, as evidenced by multiple follicular development, clinically significant ovarian enlargement or excessive estradiol production.

    What are the possible side effects of Ovidrel® PreFilled Syringe?

    Your doctor should review with you the risks and benefits of using Ovidrel® PreFilled Syringe. As with any medication, report any and all side effects, symptoms, or physical changes to your doctor.

    Ovidrel® PreFilled Syringe can cause serious side effects including ovarian hyperstimulation syndrome (OHSS) and lung and blood vessel problems. Contact your healthcare provider if you experience severe pain or bloating in the stomach or pelvic area, severe upset stomach, vomiting, or weight gain.

    Use of fertility drugs can be associated with fertilization of more than one egg. This can lead to complications for the mother and the birth of two or more babies.

    The most common side effects in women using Ovidrel® PreFilled Syringe include abdominal pain, nausea, and vomiting. Needle injections may cause some discomfort.

    US‐HCG‐0614‐0002(1)

    • Gonal-f® RFF Redi-ject® (follitropin alfa injection)

    • Gonal-f® Multi-Dose (follitropin alfa for injection)

    • Gonal-f® RFF 75 IU (follitropin alfa for injection)

    • Cetrotide® (cetrorelix acetate for injection)

    • Ovidrel® PreFilled Syringe (choriogonadotropin alfa injection)